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Losing them would leave gaps in both the game's worldbuilding and the player's party composition. Additionally, the various pre-named NPCs who can join the player's party have unique dialogue in a range of situations, and can learn some very useful skills. You are a Desert Ranger, fighting a losing battle to keep your beloved Arizona alive, when the self-proclaimed Patriarch of Colorado radios, promising aid if you will do a job he can only entrust to an outsiderrescue his land from the ambitions of his three bloodthirsty children. As cybernetic upgrades take time to acquire and install, this would be quite a waste. In Wasteland 3 the fate of Arizona depends on the fate of Colorado.
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That said, player characters who die will likely take their cybernetic augmentations with them. That said, recruiting and redistributing stats now both cost money, limiting how players can use these features. Plus, the Death and Taxes update goes further to allow already-created characters to be re-spec'd, which was not previously possible. What's more, these characters scale to the party's level, meaning one can replace fallen characters with nearly identical ones. Namely, the player can generate new party members in Colorado Springs' Ranger HQ at any time.
WASTELAND 3 UPDATE UPDATE
The developer provided an update on the current state of the game, confirming that patch. There is still one factor that makes the permadeath option less sadistic than it could be. Amid all of the games receiving year-end updates, inXile Entertainment’s Wasteland 3 is worth mentioning.
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